Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.727
Index Copernicus  – 152.95 pts
MNiSW – 40 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2015, vol. 24, nr 6, November-December, p. 957–964

doi: 10.17219/acem/27909

Publication type: original article

Language: English

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The Analgesic, Anti-Inflammatory and Anti-Pyretic Activities of Tinospora cordifolia

Liaqat Hussain1,A,B,C,D, Muhammad S. H. Akash1,A,D,E,F, Noor-Ul Ain1,B,C, Kanwal Rehman2,D,E,F, Muhammad Ibrahim3,E

1 Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan

2 Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan

3 Department of Applied Chemistry and Biochemistry, Government College University, Faisalabad, Pakistan


Background. Tinospora cordifolia (T. cordifolia) is a valuable resource due to its traditional uses in the treatment of pain, fever and inflammation, but no sufficient scientific literature is available online to confirm its traditional uses in these ailments.
Objectives. This study was carried out to validate the traditional uses of T. cordifolia in treating pain, inflammation and pyrexia, using albino mice as an experimental animal model.
Material and Methods. The analgesic effects of T. cordifolia extract were assessed by using the acetic acid-induced writhing test, hot plate test and tail-flick test. The carrageenan test was performed to assess anti-inflammatory potential, and anti-pyretic activity was evaluated by the brewer’s yeast-induced pyrexia method.
Results. The results showed that the T. cordifolia extract exhibited significant analgesic effects in a dose-dependent manner in the three pain models tested. The extract also exhibited significant anti-inflammatory effects in the carrageenan-induced inflammation test and antipyretic effects in the brewer’s yeast-induced pyrexia test in dose-dependent manner compared to the effects observed in the control group animals.
Conclusion. From the findings of the present study, it can be concluded that T. cordifolia extract has strong analgesic, anti-inflammatory and anti-pyretic effects. Further studies are required to investigate the therapeutic activities of the phytochemical constituents of T. cordifolia against pain, inflammation and pyrexia.

Key words

anti-inflammatory, anti-pyretic, experimental model, Tinospora cordifolia

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