Advances in Clinical and Experimental Medicine

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Advances in Clinical and Experimental Medicine

2019, vol. 28, nr 8, August, p. 1005–1011

doi: 10.17219/acem/94150

Publication type: original article

Language: English

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Creative Commons BY-NC-ND 3.0 Open Access

Relationship between quantitative parameters of lumbar vertebral perfusion and bone mineral density (BMD) in postmenopausal women

Zhenhuan Huang1,A,B,C,D,F, Qi Lin1,E,F, Jianwen Wang1,B, Zejuan Zhan1,C, Xuezhao Tu2,A,C

1 Department of Radiology, First Hospital of Longyan of Fujian Medical University, China

2 Department of Orthopedics, First Hospital of Longyan of Fujian Medical University, China

Abstract

Background. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a noninvasive method to evaluate the microcirculation of bone marrow in local tissue, which will be a new tool for the diagnosis of osteoporosis.
Objectives. To investigate the relationship between quantitative perfusion parameters (Ktrans, Kep and Ve) and bone mineral density (BMD) in postmenopausal women.
Material and Methods. The subjects were divided into 3 groups according to T value: normal bone mass group (T value ≥−1.0); bone loss group (−2.5 < T <−1.0); and osteoporosis group (T ≤−2.5). Ktrans, Kep and Ve of the lumbar spine were measured using quantitative DCE-MRI. The relationship between these parameters and age was analyzed.
Results. Bone mineral density of the lumbar spine and femoral neck gradually decreased with age. The values of Ktrans, Kep and Ve significantly decreased with age. The values of Ktrans, Kep and Ve of the lumbar vertebrae in the osteoporosis group were lower than those in the bone loss and normal bone mass group. Bone mineral density was positively correlated with the Ktrans and Ve of the lumbar vertebrae.
Conclusion. The incidences of bone loss and osteoporosis increased with age. The measurement of BMD was conducive to early diagnosis of osteoporosis. Ktrans, Kep and Ve values of the lumbar vertebra decreased with age, and have a positive correlation with lumbar BMD. The value of DCE-MRI may play a role in the diagnostic algorithm of osteoporosis.

Key words

osteoporosis, bone mineral density (BMD), quantitative dynamic contrast-enhanced magnetic resonance (DCE-MRI), quantitative parameters

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