Advances in Clinical and Experimental Medicine

Adv Clin Exp Med
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Advances in Clinical and Experimental Medicine

2019, vol. 28, nr 2, February, p. 193–198

doi: 10.17219/acem/76375

Publication type: original article

Language: English

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Creative Commons BY-NC-ND 3.0 Open Access

Clinical and nutritional correlations in Parkinson’s disease: Preliminary report

Sławomir Budrewicz1,A,E,F, Anna Zmarzły2,B, Dominik Rączka2,B, Aleksandra Szczepańska1,C, Ewa Koziorowska-Gawron1,B,D, Krzysztof Słotwiński1,C,D, Magdalena Koszewicz1,D,E,F

1 Department of Neurology, Wroclaw Medical University, Poland

2 Clinical Nutrition Unit, J. Gromkowski Regional Specialist Hospital, Wrocław, Poland

Abstract

Background. Parkinson’s disease (PD) is one of the most common neurodegenerative disorders. Malnutrition is an essential problem in the late stage of PD. Lowering of body mass is seen in 30% of patients, and malnutrition or the risk of malnutrition in 24% and 60%, respectively.
Objectives. The aim of the study was an analysis of the relationships between the parameters of the nutritional stage and the advancement of clinical symptoms in PD patients.
Material and Methods. A total of 40 patients (18 men, 22 women) with PD were analyzed, mean age: 70.7 years. In all patients, structured anamnesis, Nutrition Risk Screening (NRS 2002), body mass index (BMI), morphology, and basic biochemical tests were conducted. Skin fold thickness was also measured. The results were referred to the score of different scales.
Results. The study showed a lot of correlations between the severity of PD, mostly motor symptoms in the Unified Parkinson’s Disease Rating Scale (UPDRS), and parameters characterizing the patient’s nutritional status. We revealed a correlation between malnutrition and PD duration, and l-DOPA frequency intake. The global score of parts I, II and III of UPDRS were correlated with the nutritional status. The results confirmed the existence of more severe smell change and taste impairment in the late stage of PD, with more pronounced malnutrition.
Conclusion. The duration of PD, motor and non-motor PD symptoms, and the frequency of l-DOPA intake closely correlate with the nutritional status. Understanding of the multifactorial interdependence might be useful in the estimation of the algorithm for monitoring the nutritional status of PD patients and taking early nutritional intervention.

Key words

malnutrition, Parkinson’s disease, Nutrition Risk Screening, Unified Parkinson’s Disease Rating Scale, skin fold thickness

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