Advances in Clinical and Experimental Medicine

Adv Clin Exp Med
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Advances in Clinical and Experimental Medicine

2018, vol. 27, nr 7, July, p. 955–962

doi: 10.17219/acem/70567

Publication type: original article

Language: English

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Creative Commons BY-NC-ND 3.0 Open Access

L-FABP and IL-6 as markers of chronic kidney damage in children after hemolytic uremic syndrome

Katarzyna Lipiec1,A,B,C,D,F, Piotr Adamczyk2,C,D,F, Elżbieta Świętochowska3,B,C, Katarzyna Ziora2,E, Maria Szczepańska2,A,C,E,F

1 Department of Pediatric Nephrology with Dialysis Division for Children, Zabrze, Poland

2 Department and Clinic of Pediatrics, SMDZ in Zabrze, SUM in Katowice, Poland

3 Chair and Department of Medical and Molecular Biology, SMDZ in Zabrze, SUM in Katowice, Poland

Abstract

Background. Hemolytic-uremic syndrome (HUS) is a form of thrombotic microangiopathy, in the course of which some patients may develop chronic kidney disease (CKD). From a clinical point of view, it is important to search for markers that allow for early identification of patients at risk of a poor prognosis.
Objectives. The study evaluated the serum and urine levels of liver-type fatty acid binding protein (L-FABP) and interleukin 6 (IL-6).
Material and Methods. The study was conducted in 29 children with a history of HUS. The relationship between L-FABP and IL-6 and anthropometric measurements, the value of estimated glomerular filtration rate (eGFR) and albuminuria were additionally evaluated.
Results. In children after HUS, L-FABP and IL-6 concentration in both serum and urine was significantly higher in comparison to the control group. No differences in L-FABP and IL-6 concentration in serum and urine depending on the type of HUS and gender were noted. Correlation between L-FABP and IL-6 in serum and urine with eGFR and urine albumin-creatinine ratio (ACR) in the total group of patients after HUS was not detected. In the group of children after 6 month observation after HUS, a negative correlation of L-FABP concentration with eGFR was found.
Conclusion. The results indicate that the higher concentration of L-FABP in serum and urine of children with a history of HUS can be the result of protracted injury initiated during the acute phase of the disease. Lack of correlation of L-FABP concentration with the ACR may be associated with a short (less than 6 months) observation after acute renal failure or merely temporary renal tubular damage in the acute phase of the disease. In contrast, higher levels of IL-6 in serum and urine in children after HUS compared to healthy children and the negative correlation of L-FABP concentration and eGFR in children after 6 month observation after HUS may confirm their participation in CKD. Thus, L-FABP and IL-6 seem to be good biomarkers of chronic kidney damage in survivors of the acute phase of HUS.

Key words

children, interleukin 6, chronic kidney disease, hemolytic-uremic syndrome, liver-type fatty acid binding protein

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