Advances in Clinical and Experimental Medicine

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Advances in Clinical and Experimental Medicine

2017, vol. 26, nr 5, August, p. 835–842

doi: 10.17219/acem/61434

Publication type: original article

Language: English

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Creative Commons BY-NC-ND 3.0 Open Access

Serum ICAM-1, VCAM-1 and E-selectin levels in patients with primary and secondary Sjögren’s syndrome

Katarzyna J. Błochowiak1,A,B,C,D,F, Anna Olewicz-Gawlik2,A,B,E,F, Dorota Trzybulska2,C,D,E,F, Michalina Nowak-Gabryel3,B,E,F, Jarosław Kocięcki3,E,F, Henryk Witmanowski4,E,F, Jerzy Sokalski1,A,E,F

1 Department of Oral Surgery, Poznan University of Medical Sciences, Poland

2 Department of Rheumatology and Clinical Immunology, Poznan University of Medical Sciences, Poland

3 Department of Ophthalmology, Poznan University of Medical Sciences, Poland

4 Department of Plastic, Reconstructive and Aesthetic Surgery, Nicolaus Copernicus University Torun, Collegium Medicum, Bydgoszcz, Poland

Abstract

Background. Typical features of Sjögren’s syndrome (SS) are severe xerostomia and xerophthalmia which are basic diagnostic criteria.
Objectives. The aim of this study was to compare the serum levels of soluble (s) intercellular adhesion molecule 1 (sICAM-1), vascular cell adhesion molecule 1 (sVCAM-1) and sE-selectin between primary (pSS), secondary (sSS) and healthy subjects (HS). We correlated these results with selected clinical parameters of disease activity and parameters of the severity of xerostomia and xerophthalmia.
Material and Methods. The serum levels of sICAM-1, sVCAM-1 and sE-selectin were determined by enzyme-linked immunosorbent assay (ELISA) in 16 patients with pSS, 18 with sSS and 15 HS. Eye dryness and xerostomia were assessed by the Schirmer’s test, the Fox test and the visual analogue scale (VAS).
Results. The levels of sICAM-1 in pSS and sVCAM-1 in sSS patients were significantly higher when compared to HS (p = 0.02 and p = 0.048, respectively). There were no differences between pSS and sSS. In pSS, sVCAM-1 correlated positively with VAS (rS = 0.52, p = 0.04) and the Fox test (rS = 0.66, p=0.01). In sSS, sE-selectin correlated positively with sICAM-1 (rS = 0.54, p = 0.01), the duration of the disease (rS = 0.51, p = 0.03) and negatively with the Schirmer’s test (rS = 0.59, p = 0.04). sICAM-1 correlated positively with the erythrocyte sedimentation rate (ESR) value (rS = 0.59, p = 0.01).
Conclusion. sVCAM-1 reflects xerostomia in pSS. sICAM-1 and sE-selectin may be additional parameters of sSS activity.

Key words

Sjögren’s syndrome, xerostomia, sICAM-1, sE-selectin, sVCAM-1

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