Advances in Clinical and Experimental Medicine

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Advances in Clinical and Experimental Medicine

2017, vol. 26, nr 5, August, p. 795–801

doi: 10.17219/acem/64023

Publication type: original article

Language: English

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Creative Commons BY-NC-ND 3.0 Open Access

Evaluation of the anterior chamber angle in pseudoexfoliation syndrome

Małgorzata Iwanejko1,A,B,C,F, Anna Turno-Kręcicka1,D,E,F, Martyna Tomczyk-Socha1,D,E, Kamil Kaczorowski1,E,F, Andrzej Grzybowski2,3,F, Marta Misiuk-Hojło1,F

1 Department and Clinic of Ophthalmology, Wroclaw Medical University, Poland

2 Department of Ophthalmology, Poznan City Hospital, Poznań, Poland

3 Deptartment of Ophthalmology, University of Warmia and Mazury, Olsztyn, Poland


Background. Pseudoexfoliation syndrome (PEX) is the most frequently identifiable cause of secondary open-angle glaucoma, known as pseudoexfoliation glaucoma. The exact pathophysiology and etiology of PEX and associated glaucoma remains obscure.
Objectives. The purpose of this study was to determine the differences in the morphology of the anterior chamber angle in people with pseudoexfoliation syndrome and pseudoexfoliation glaucoma compared to a control group. We also evaluated the correlation between intraocular pressure (IOP) and pigmentation of the angle with the amount of exfoliated material in the anterior segment.
Material and Methods. The study group was composed of 155 eyes from 103 patients aged between 43 and 86 years. Each patient underwent a complete ophthalmological examination.
Results. Some difference was found in intraocular pressure between the PEX group and the control group and between the pseudoexfoliation glaucoma group and the control group, but no significant difference was found between the 2 study groups. There was a significant difference in the incidence of some degree of pigmentation in the anterior chamber angle and no difference in the widths of the angle between each group. A significant positive relationship was observed between intraocular pressure and the degree of pigmentation of the anterior chamber angle in both the PEX group and the pseudoexfoliation glaucoma group.
Conclusion. The results of this study indicate that the amount of pigmentation and exfoliation material in the anterior segment significantly correlates with the level of IOP and possibly with the degree of trabecular dysfunction. It seems that for clear identification of PEX and pseudoexfoliation glaucoma factors, clinical assessment appears to be insufficient.

Key words

pseudoexfoliation syndrome, PEX, pseudoexfoliation glaucoma, PEXG, morphology of the ocular angle

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