Advances in Clinical and Experimental Medicine

Adv Clin Exp Med
Impact Factor (IF) – 1.262
Index Copernicus (ICV) – 155.19, MNiSW – 15
Rejection rate – 65.13%
License – Creative Commons (CC BY-NC-ND 4.0)
ISSN 1899–5276 (print),   ISSN 2451-2680 (online)
Periodicity – monthly

Download PDF

Advances in Clinical and Experimental Medicine

2015, vol. 24, nr 5, September-October, p. 749–758

doi: 10.17219/acem/31802

Publication type: editorial article

Language: English

Download citation:

  • BIBTEX (JabRef, Mendeley)
  • RIS (Papers, Reference Manager, RefWorks, Zotero)

Creative Commons BY-NC-ND 3.0 Open Access

Recent Developments in the Application of Polymeric Nanoparticles as Drug Carriers

Michał Moritz1,A,B,C,D,E,F, Małgorzata Geszke-Moritz2,A,B,C,D,E,F

1 Department of General and Analytical Chemistry, Faculty of Chemical Technology, Institute of Chemistry and Technical Electrochemistry, Poznan University of Technology, Poland

2 NanoBioMedical Centre, Adam Mickiewicz University, Poznań, Poland


Nanotechnology is an interdisciplinary field of science offering interesting solutions for many branches of human life. Nanomaterials, defined as structures with at least one dimension below 100 nm, are the focus of increasing research attention as versatile tools for nanomedicine. Among the various nanostructures recently described in the literature, polymeric nanoparticles, characterized by satisfying biocompatibility, have aroused great interest as the carriers for various biologically active substances such as drugs, proteins and nucleic acids. These nanoparticles have already been reported as efficient vehicles for therapeutic agents in many disease entities. They can be delivered to the body via different administration routes. This review addresses recent advances in the usage of polymeric nanoparticles as drug carriers described in the years 2013 and 2014. The advantages of polymeric nanocarriers for medical application are highlighted, including their low toxicity, evaluated in vitro and in vivo. Moreover, the classification of polymeric nanoparticles is presented as well as various protocols of their synthesis.

Key words

biocompatibility, polymeric nanoparticles, drug carrier, nanomedicine

References (40)

  1. Moritz M, Geszke-Moritz M: Application of nanomaterials in medical sciences. Chemik 2012, 66, 219–226.
  2. Geszke-Moritz M, Moritz M: Quantum dots as versatile probes in medical sciences: Synthesis, modification and properties. Mater Sci Eng C 2013, 33, 1008–1021.
  3. Yang K, Feng L, Shi X, Liu Z: Nano-graphene in biomedicine: theranostic applications. Chem Soc Rev 2013, 42, 530–547.
  4. Battigelli A, Ménard-Moyon C, Ros TD, Prato M, Bianco A: Endowing carbon nanotubes with biological and biomedical properties by chemical modifications. Adv Drug Delivery Rev 2013, 65, 1899–1920.
  5. Moritz M, Geszke-Moritz M: The newest achievement in synthesis, immobilization and practical applications of antibacterial nanoparticles. Chem Eng J 2013, 228, 596–613.
  6. Han S, Li M, Liu X, Gao H, Wu Y: Construction of amphiphilic copolymer nanoparticles based on gelatin as drug carriers for doxorubicin delivery. Colloids Surf B 2013, 102, 833–841.
  7. Kulhari H, Pooja D, Shrivastava S, Naidu VGM, Sistla R: Peptide conjugated polymeric nanoparticles as a carrier for targeted delivery of docetaxel. Colloids Surf B 2014, 117, 166–173.
  8. Shah U, Joshi G, Sawant K: Improvement in antihypertensive and antianginal effects of felodipine by enhanced absorption from PLGA nanoparticles optimized by factorial design. Mater Sci Eng C 2014, 35, 153–163.
  9. Katiyar S, Pandit J, Mondal RS, Mishra AK, Chuttani K, Aqil M, Ali A, Sultana Y: In situ gelling dorzolamide loaded chitosan nanoparticles for the treatment of glaucoma. Carbohydr Polym 2014, 102, 117–124.
  10. Reyes-Ortega F, Rodríguez G, Aguilar MR, Lord M, Whitelock J, Stenzel MH, Román JS: Encapsulation of low molecular weight heparin (bemiparin) into polymeric nanoparticles obtained from cationic block copolymers: properties and cell activity. J Mater Chem B 2013, 1, 850–860.
  11. Alai M, Lin WJ: Novel lansoprazole-loaded nanoparticles for the treatment of gastric acid secretion-related ulcers: In vitro and in vivo pharmacokinetic pharmacodynamic evaluation. Amer Assoc Pharm Sci J 2014, DOI: 10.1208/ /s12248-014-9564-0.
  12. Varshosaz J, Taymouri S, Hamishehkar H: Fabrication of polymeric nanoparticles of poly(ethylene-co-vinyl acetate) coated with chitosan for pulmonary delivery of carvedilol. J Appl Polym Sci 2014, 131, 39694–39701.
  13. Zhao J, Feng SS: Effects of PEG tethering chain length of vitamin E TPGS with a Herceptin-functionalized nanoparticle formulation for targeted delivery of anticancer drugs. Biomaterials 2014, 35, 3340–3347.
  14. Pu HL, Chiang WL, Maiti B, Liao ZX, Ho YC, Shim MS, Chuang EY, Xia Y, Sung HW: Nanoparticles with dual responses to oxidative stress and reduced pH for drug release and anti-inflammatory applications. ACS Nano 2014, 8, 1213–1221.
  15. Thambi T, Deepagan VG, Yoon HY, Han HS, Kim SH, Son S, Jo DG, Ahn CH, Suh YD, Kim K, Kwon IC, Lee DS, Park JH: Hypoxia-responsive polymeric nanoparticles for tumor-targeted drug delivery. Biomaterials 2014, 35, 1735–1743.
  16. Zhang X, Chen G, Wen L, Yang F, Shao A, Li X, Long W, Mu L: Novel multiple agents loaded PLGA nanoparticles for brain delivery via inner ear administration: In vitro and in vivo evaluation. Eur J Pharm Sci 2013, 48, 595–603.
  17. Zhang X, Dong Y, Zeng X, Liang X, Li X, Tao W, Chen H, Jiang Y, Mei L, Feng SS: The effect of autophagy inhibitors on drug delivery using biodegradable polymer nanoparticles in cancer treatment. Biomaterials 2014, 35, 1932–1943.
  18. Narayanan D, Geena MG, Lakshmi H, Manzoor K, Shantikumar N, Menon D: Poly-(ethylene glycol) modified gelatin nanoparticles for sustained delivery of the anti-inflammatory drug ibuprofen-sodium: An in vitro and in vivo analysis. Nanomedicine: NBM 2013, 9, 818–828.
  19. Forbes DC, Peppas NA: Polycationic nanoparticles for siRNA delivery: Comparing ARGET ATRP and UV-initiated formulations. ACS Nano 2014, 8, 2908–2917.
  20. He C, Yin L, Tang C, Yin C: Multifunctional polymeric nanoparticles for oral delivery of TNF-α siRNA to macrophages. Biomaterials 2013, 34, 2843–2854.
  21. Hill LE, Taylor TM, Gomes C: Antimicrobial efficacy of poly(DL-lactide-co-glycolide) (PLGA) nanoparticles with entrapped cinnamon bark extract against Listeria monocytogenes and Salmonella typhimurium. J Food Sci 2013, 78, 626–632.
  22. Yoo D, Guk K, Kim H, Khang G, Wu D, Lee D: Antioxidant polymeric nanoparticles as novel therapeutics for airway inflammatory diseases. Int J Pharm 2013, 450, 87–94.
  23. Zakeri-Milani P, Loveymi BD, Jelvehgari M, Valizadeh H: The characteristics and improved intestinal permeability of vancomycin PLGA-nanoparticles as colloidal drug delivery system. Colloids Surf B 2013, 103, 174–181.
  24. Chaudhary SH, Kumar V: Taguchi design for optimization and development of antibacterial drug-loaded PLGA nanoparticles. Int J Biol Macromol 2014, 64, 99–105.
  25. Sinha B, Mukherjee B, Pattnaik G: Poly-lactide-co-glycolide nanoparticles containing voriconazole for pulmonary delivery: in vitro and in vivo study. Nanomedicine: NBM 2013, 9, 94–104.
  26. De Carvalho RF, Ribeiro IF, Miranda-Vilela AL, Filho J de Sousa, Martins OP, Cintra e Silva Dde O, Tedesco AC, Lacava ZGM, Báo SN, Sampaio RNR: Leishmanicidal activity of amphotericin B encapsulated in PLGADMSA nanoparticles to treat cutaneous leishmaniasis in C57BL/6 mice. Exp Parasitol 2013, 135, 217–222.
  27. Sabzevari A, Adibkia K, Hashemi H, Hedayatfar A, Mohsenzadeh N, Atyabi F, Ghahremani MH, Dinarvand R: Polymeric triamcinolone acetonide nanoparticles as a new alternative in the treatment of uveitis: In vitro and in vivo studies. Eur J Pharm Biopharm 2013, 84, 63–71.
  28. Palange AL, Mascolo DD, Carallo C, Gnasso A, Decuzzi P: Lipid-polymer nanoparticles encapsulating curcumin for modulating the vascular deposition of breast cancer cells. Nanomedicine: NBM 2014, DOI: 10.1016/j. nano.2014.02.004.
  29. Tiwari SK, Agarwal S, Seth B, Yadav A, Nair S, Bhatnagar P, Karmakar M, Kumari M, Chauhan LKS, Patel DK, Srivastava V, Singh D, Gupta SK, Tripathi A, Chaturvedi RK, Gupta KC: Curcumin-loaded nanoparticles potently induce adult neurogenesis and reverse cognitive deficits in Alzheimer’s disease model via canonical W nt/β-catenin pathway. ACS Nano 2014, 8, 76–103.
  30. Hussain Z, Katas H, Amin MCIM, Kumolosasi E, Buang F, Sahudin S: Self-assembled polymeric nanoparticles for percutaneous co-delivery of hydrocortisone/hydroxytyrosol: An ex vivo and in vivo study using an NC/Nga mouse model. Int J Pharm 2013, 444, 109–119.
  31. Hao S, Wang B, Wang Y, Xu Y: Enteric-coated sustained-release nanoparticles by coaxial electrospray: preparation, characterization, and in vitro evaluation. J Nanopart Res 2014, 16, 2204–2214.
  32. Jana S, Maji N, Nayak AK, Sen KK, Basu SK: Development of chitosan-based nanoparticles through inter-polymeric complexation for oral drug delivery. Carbohydr Polym 2013, 98, 870–876.
  33. Dionísio M, Cordeiro C, Remuñán-López C, Seijo B, da Costa AMR, Grenha A: Pullulan-based nanoparticles as carriers for transmucosal protein delivery. Eur J Pharm Sci 2013, 50, 102–113.
  34. Bae J, Nael MA, Jiang L, Hwang PT, Mahdi F, Jun H-W, Elshamy WM, Zhou YD, Murthy SN, Doerksen RJ, Jo S: Quinone propionic acid-based redox-triggered polymer nanoparticles for drug delivery: Computational analysis and in vitro evaluation. J Appl Polym Sci 2014, 131, 40461–40470.
  35. Phan CM, Subbaraman L, Liu S, Gu F, Jones L: In vitro uptake and release of natamycin Dex-b-PLA nanoparticles from model contact lens materials. J Biomater Sci, Polym Ed 2014, 25, 18–31.
  36. Hazra C, Kundu D, Chatterjee A, Chaudhari A, Mishra S: Poly(methyl methacrylate) (core)-biosurfactant (shell) nanoparticles: Size controlled sub-100 nm synthesis, characterization, antibacterial activity, cytotoxicity and sustained drug release behavior. Colloids Surf A 2014, 449, 96–113.
  37. Stevanović M, Bračko I, Milenković M, Filipović N, Nunić J, Filipič M, Uskoković DP: Multifunctional PLGA particles containing poly(L-glutamic acid)-capped silver nanoparticles and ascorbic acid with simultaneous antioxidative and prolonged antimicrobial activity. Acta Biomater 2014, 10, 151–162.
  38. Papa S, Ferrari R, de Paola M, Rossi F, Mariani A, Caron I, Sammali E, Peviani M, Dell’Oro V, Colombo C, Morbidelli M, Forloni G, Perale G, Moscatelli D, Veglianese P: Polymeric nanoparticle system to target activated microglia/macrophages in spinal cord injury. J Controlled Release 2014, 174, 15–26.
  39. Kwon J, Kim J, Park S, Khang G, Kang PM, Lee D: Inflammation-responsive antioxidant nanoparticles based on a polymeric prodrug of vanillin. Macromolecules 2013, 14, 1618–1626.
  40. Shi P, Aluri S, Lin Y-A, Shah M, Edman M, Dhandhukia J, Cui H, MacKay JA: Elastin-based protein polymer nanoparticles carrying drug at both corona and core suppress tumor growth in vivo. J Controlled Release 2013, 171, 330–338.