Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 2.1
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ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2014, vol. 23, nr 5, September-October, p. 821–825

Publication type: original article

Language: English

The Effects of Total Abdominal Hysterectomy on Ovarian Function – Serial Changes in Serum Anti-Müllerian Hormone, FSH and Estradiol Levels

Levent Gökgözoğlu1,A,B,C, Mine İslimye2,A,B, Hasan Onur Topçu3,D,E,F, Utku Özcan3,E,F

1 Giresun Bulancak State Hospital, Giresun, Turkey

2 Department of Obstetrics and Gynecology, Balıkesir Univesity, Balıkesir, Turkey

3 Zekai Tahir Burak Women’s Health Education and Research Hospital, Ankara, Turkey

Abstract

Objectives. The aim of this study was to evaluate ovarian function with longitudinal changes in serum levels of anti-mullerian hormone (AMH), follicle stimulating hormone (FSH) and estradiol (E2) after total abdominal hysterectomy (TAH) with ovarian conservation.
Material and Methods. In this prospective longitudinal study, a total of 29 women, aged 39 to 48 years, suffering from uterine pathologies underwent TAH with ovarian conservation. Their serum AMH, FSH and E2 levels were measured at baseline, at the first month and the third month after TAH.
Results. There was a statistically significant decrease in AMH serum levels between the baseline and the first postoperative month; the values were 0.22 (0.16–1.49) ng/mL and 0.18 (0.04–0.52) ng/mL, respectively. However, significant differences were not seen for serum levels of FSH and E2 when baseline and one-month values were compared. In addition, no statistically significant differences were detected between the baseline and third-month serum AMH, FSH and E2 levels.
Conclusion. The study demonstrated that TAH affects ovarian function temporarily.

Key words

anti-mullerian hormone, hysterectomy, ovarian conservation.

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