Advances in Clinical and Experimental Medicine

Adv Clin Exp Med
Impact Factor (IF) – 1.262
Index Copernicus (ICV) – 155.19, MNiSW – 15
Rejection rate – 65.13%
License – Creative Commons: Attribution 3.0 Unported (CC BY 3.0)
ISSN 1899–5276 (print),   ISSN 2451-2680 (online)
Periodicity – monthly

Download PDF

Advances in Clinical and Experimental Medicine

2014, vol. 23, nr 5, September-October, p. 675–681

Publication type: editorial article

Language: English

Celiac Disease and Its Impact on the Oral Health Status – Review of the Literature

Barbara Krzywicka1,A,B,C,D,F, Katarzyna Herman1,B,C,D,E,F, Małgorzata Kowalczyk-Zając1,B,D,F,G, Tomasz Pytrus2,B,D,E

1 Department of Conservative Dentistry and Pedodontics, Wroclaw Medical University, Poland

2 Department of Pediatrics, Gastroenterology and Nutrition, Wroclaw Medical University, Poland

Abstract

The paper presents the most recent reports on celiac disease, especially its manifestations within the oral cavity. Particular attention should be paid to typical dental enamel defects with a various degree of advancement: discolorations, horizontal groves and pits, and even significant structural destruction causing the change of the dental crown. Symmetric location of defects within all dentition sections, and within the same anatomic groups of teeth (the most frequently: incisors and first permanent molars), is specific for celiac disease. The changes described above may be the only manifestation of celiac disease; therefore, in the case of their occurrence further studies towards gluten intolerance are recommended even when other symptoms are not present. In celiac patients, recurrent aphthae and other disorders of the oral mucosa such as ulceration, erythema, atrophic glossitis, as well as dryness and a burning sensation (particularly of the tongue) may be present, which may be caused by malnutrition. Delayed tooth eruption may also be a consequence of alimentary deficiency in celiac disease.

Key words

celiac disease, developmental enamel defects, aphthae, delayed tooth eruption.

References (39)

  1. Marsh MN: Gluten, major histocompatibility complex and the small intestine. Gastroenterology 1992, 102, 330–354.
  2. Hill ID, Dirks MH, Liptak GS, Coletti RB, Fasano A, Guandalini S, Hoffenberg EJ, Horvath K, Murray JA, Pivor M, Seidman EG: Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 2005, 40, 1–19.
  3. Rivera E, Assiri A, Guandalini S: Celiac Disease. Oral Dis 2013, doi: 10.1111/odi 12091, 1–7.
  4. Husby S, Koletzko S, Korponay-Szabo IR: ESPGHAN guidelines for the diagnosis of coeliac disease in children and adolescents. An evidence – based approach. J Pediatr Gastroenterol Nutr 2012, 54, 136–160.
  5. Iwańczak F, Iwańczak B: Nowe wytyczne dotyczące diagnostyki i leczenia choroby trzewnej u dzieci i młodzieży. Przegl Gastroenterol 2012, 7, 4, 185–191.
  6. Aine L, Mäki M, Collin P, Keyrilläinen O: Dental Enamel Defects in celiac disease. J Oral Pathol Med 1990, 19, 241–245.
  7. Campisi G, Di Liberto C, Iacono G, Compilato D, Di Prima L, Calvino F, Di Marco V, Lo Muzio L, Sferrazza C, Scalici C, Craxi A, Carroccio A: Oral pathology in untreated coeliac disease. Aliment Pharmacol Ther 2007, 26, 1529–1536.
  8. Ortega Paez E, Junco Lafuente P, Baca Garcia P, Maldonado Lozano J, Llodra Calvo JC: Prevalence of dental enamel defects in celiac patients with deciduous dentition: a pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008, 106, 74–78.
  9. Cheng J, Malahias T, Brar P, Minaya MT, Green PH: The association between celiac disease, dental enamel defects, and aphtous ulcers in a United States cohort. J Clin Gastroenterol 2010, 44, 191–194.
  10. Wiernik CD, van Diermen DE, Aartman IH, Heymans HS: Dental enamel defects in children with coeliac disease. Int J Paediatr Dent 2007, 17, 136–138.
  11. Acar S, Yetkiner AA, Ersin N, Oncag O, Aydogdu S, Arikan C: Oral findings and salivary parameters in children with celiac disease: a preliminary study. Med Princ Prac 2012, 21, 129–133.
  12. Postek-Stefańska L, Kalacińska J, Wacławczyk A, Kupczyński P: Stan zdrowia jamy ustnej u pacjentów z celiakią. Dent Med Probl 2009, 46, 168–176.
  13. Shetyer E, Berson T, Lachmanovitz O, Hidas A, Wilschanski M, Meneachem M, Shachar E, Shapira J, Steinberg D, Moskovitz M: Oral health status and salivary properties in relation to gluten free diet in children with celiac disease. J Pediatr Gastroenterol Nutr 2013, 57, 1, 49–52.
  14. Farmakis E, Puntis JW, Toumba KJ: Enamel defects in children with coeliac disease. Eur J Paediatr Dent 2005, 6, 129–132.
  15. Skrzelewska K, Czerwonka-Szaflarska M: Analiza zmian w jamie ustnej u dzieci, młodzieży i dorosłych z chorobą trzewną. Przegl Pediatr 2004, 34, 21–25.
  16. Costacurta M, Maturo P, Bartolino M, Docimo R: Oral manifestation of coeliac disease. Oral Implantol 2010, 3, 12–19.
  17. Priovolou CH, Vaderas AP, Papaginnoulis L: A comparative study on the prevalence of enamel defects and dental caries in children and adolescents with and without coeliac disease. Eur J Paediatr Dent 2004, 5, 102–106.
  18. Bucci P, Carile F, Sangianantoni A, D’Angio F, Santarelli A, Lo Muzio L: Oral aphtosus ulcers and dental enamel defects in children with coeliac disease. Acta Paediatr 2006, 95, 203–207.
  19. Trotta L, Biagi F, Bianchi PI, Marchese A, Vattiato C, Balduzzi D, Collesano V, Corazza GR: Dental enamel defects in adult coeliac disease: prevalence and correlation with symptoms and age at diagnosis. Eur J Intern Med 2013, 24, 832–834.
  20. Aine L: Dental enamel defects and dental maturity in children and adolescents with coeliac disease. Proc Finn Dent Soc 1986, 82, 1–71.
  21. Rashid M, Zarkadas M, Anca A, Limeback H: Oral manifestations of coeliac disease: a clinical guide for dentists. J Mich Dent Assoc 2011, 93, 42–46.
  22. Bossu M, Bartoli A, Orsini G, Luppino E, Polimeni A: Enamel hypoplasia in coeliac children: a potential clinical marker of early diagnosis. Eur J Paediatr Dent 2007, 8, 31–37.
  23. Cameron AC: Stomatologia dziecięca. Elsevier Urban&Partner, Wrocław 2008, wyd. 3, 248–257, 458–459.
  24. Mina SS, Azcurra AI, Dorronsoro S, Brunotto MN: Alterations of the oral ecosystem in children with celiac disease. Acta Odontol Latinoam 2008, 21, 121–126.
  25. Avsar A, Kalayci AG: The presence and distribution of enamel defects and caries in children with celiac disease. Turk J Pediatr 2008, 50, 45–50.
  26. Nikiforuk G, Fraser D: The etiology of enamel hypoplasia: a unifying concept. J Pediatr 1981, 98, 888–893.
  27. El-Hodhod MA, El-Agouza IA, Abdel-Al H, Kabil NS, Bayomi KA: Screening for celiac disease in children with dental enamel defects. ISRN Pediatr 2012, 763783. doi: 10.5402/2012/763783.
  28. Mariani P, Mazilli MC, Margutti G, Lionetti P, Triglione P, Petronzelli F: Coeliac disease, enamel defects and HLA typing. Acta Paediatr 1994, 83, 1272–1275.
  29. Erriu M, Abbate GM, Pili FM, Novara F, Orru G, Montaldo C, Piras V, Levrini L: Oral signs and HLADQB1*02 haplotypes in the celiac paediatric patient: a preliminary study. Autoimmune Dis 2013, 389590. doi:10.1155/2013/389590.
  30. Muňoz F, Del Rio N, Sónora C, Tiscornia I, Marco A, Hernandez A: Enamel defects associated with coeliac disease: putative role of antibodies against gliadin in pathogenesis. Eur J Oral Sci 2012, 120, 104–112.
  31. Condo R, Perugia C, Maturo P, Docimo R: MIH: epidemiologic clinic study in paediatric patient. Oral Implantol 2012, 5, 58–69.
  32. Lygidakis NA, Wong F, Jälevik B, Vierrou AM, Alaluusua S, Espelid I: Best clinical practice guidance for clinicians dealing with children presenting with Molar-Incisor Hypomineralization (MIH): an EAPD policy document. Eur Arch Paediatr Dent 2010, 11, 75–81.
  33. Lähteenoja H, Toivanen A, Viander M, Mäki M, Irjla K, Rähä I, Syrjänen S: Oral mucosal changes in coeliac patients on a gluten free diet. Eur J Oral Sci 1998, 106, 899–906.
  34. Tsami A, Petropoulou P, Panayiotou J, Mantzavinos Z, Roma-Giannikou E: Oral hygiene and periodontal treatment needs in children and adolescents with coeliac disease in Greece. Eur J Paediatr Dent 2010, 11, 122–126.
  35. Pastore L, Carroccio A, Compilato D, Panzarella V, Serpico R, Lo Muzio: Oral manifestations of celiac disease. J Clin Gastroenterol 2008, 42, 224–232.
  36. Marzec-Koronczewska Z: Stan narządu żucia u dzieci z glutenozależną chorobą trzewną. Czas Stomatol 1990, 43, 207–212.
  37. Romankiewicz-Woźniaczko G, Erecińska K, Kaczmarczyk J: Stan jamy ustnej u dzieci po przebytej celiakii. Wiad Lek 1973, 26, 1011–1017.
  38. Mina SS, Azcurra AI, Riga C, Cornejo LS, Brunotto M: Evaluation of clinical dental variables to build classifiers to predict celiac disease. Med Oral Patol Oral Cir Bucal 2008, 13, 398–402.
  39. Czerwionka-Szaflarska M: Choroba trzewna – celiakia. Openmedica Zdrowie 2002.02.12.