Advances in Clinical and Experimental Medicine

Adv Clin Exp Med
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Advances in Clinical and Experimental Medicine

2013, vol. 22, nr 5, September-October, p. 615–620

Publication type: original article

Language: English

Tannic Acid Influence on Lead and Cadmium Accumulation in the Hearts and Lungs of Rats

Wpływ kwasu taninowego na akumulację ołowiu i kadmu w sercach i płucach szczurów

Anna Winiarska-Mieczan1,A,B,C,D,E, Robert Krusiński2,B,E,F, Małgorzata Kwiecień2,B,E,F

1 Department of Bromatology and Food Physiology, University of Life Sciences in Lublin, Poland

2 Department of Animal Nutrition, University of Life Sciences in Lublin, Poland

Abstract

Background. The presence of heavy metals in food products has become a global problem. In order to reduce the absorption of heavy metals from food we should consider substances which bind these toxic metals and are generally available and easy to apply, such as tannins.
Objectives. The study aimed at verifying if oral administration of tannic acid could reduce the accumulation of lead and cadmium in the heart and lungs of rats subjected to a continuous exposure of toxic metals in low doses.
Material and Methods. Adolescent and adult male Wistar rats were given tannic acid (2% solution) or distilled water containing 0, 50, 100 mg Pb (as (CH3COO)2Pb)/L or 0, 7, 14 mg Cd (as CdCl2)/L, for 6 or 12 weeks.
Results. Administering a 2% solution of tannic acid alternately with Pb or Cd to the rats was the effective method of reducing lead and cadmium content in the rats’ heart and lungs.
Conclusion. The obtained results may be referred to people. It is necessary to conduct further research in order to confirm the hypothesis that tannic acid, present in numerous food products and primarily in drinks (wine, tea and coffee), used in the human diet, may reduce the accumulation of lead and cadmium in the tissues and thus weaken their toxicity, which is important regarding our common exposure to heavy metals found in food.

Streszczenie

Wprowadzenie.Obecność metali ciężkich w żywności jest problemem globalnym. Aby ograniczyć wchłanianie metali ciężkich z żywności, należy brać pod uwagę substancje wiążące te toksyczne metale, które przy okazji będą łatwe w użyciu i ogólnie dostępne, np. kwas taninowy.
Cel pracy. Sprawdzenie, czy doustne podawanie kwasu taninowego spowoduje zmniejszenie akumulacji kadmu i ołowiu w sercu oraz płucach szczurów wystawionych na stałą ekspozycję tych metali toksycznych w małych dawkach.
Materiał i metody. Rosnące i dorosłe samce szczurów Wistar otrzymywały 2% roztwór kwasu taninowego lub wodę destylowaną zawierającą 0, 50, 100 mg Pb (w postaci (CH3COO)2Pb)/L albo 0, 7, 14 mg Cd (CdCl2)/L przez 6 lub 12 tygodni.
Wyniki. Zastosowanie 2% roztworu kwasu taninowego naprzemiennie z Pb lub Cd okazało się skutecznym sposobem ograniczenia koncentracji tych metali w sercach i płucach szczurów.
Wnioski. Uzyskane wyniki można odnieść do ludzi. Należy prowadzić dalsze badania mające na celu potwierdzenie, czy stosowanie w diecie człowieka kwasu taninowego, występującego w wielu pokarmach, a przede wszystkim w napojach (wino, kawa, herbata), może ograniczyć kumulowanie ołowiu i kadmu w tkankach i tym samym osłabić ich toksyczne działanie. Jest to ważne z uwagi na powszechne narażenie ludzi na metale ciężkie, których podstawowym źródłem jest żywność.

Key words

lead, cadmium, tannic acid, accumulation, hearts, lungs, rats.

Słowa kluczowe

ołów, kadm, kwas taninowy, akumulacja, serca, płuca, szczury.

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