Advances in Clinical and Experimental Medicine

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Advances in Clinical and Experimental Medicine

2012, vol. 21, nr 3, May-June, p. 403–408

Publication type: review article

Language: English

Creative Commons BY-NC-ND 3.0 Open Access

Tryptase in Diagnosing Adverse Suspected Anaphylactic Reaction

Tryptaza w diagnostyce reakcji niepożądanych podejrzanych o anafilaksję podczas znieczulenia oraz w okresie okołooperacyjnym

Grażyna Michalska-Krzanowska1,

1 Division of Anesthesiology and Intensive Care, 111th Military Hospital with Outpatient Clinic Poznań, Poland

Abstract

Determination of serum mast cell tryptase (MCT) is becoming more widely used in diagnosing allergic reactions involving mast cells. It can help evaluate the allergenic effects of drugs administered during anesthesia and the perioperative period. Until now, data about the role of tryptase in the body has not been clarified yet. Patients with elevated MCT levels should undergo further testing to find out the causative agent of a potential allergic reaction. Patients with normal tryptase concentration should also undergo further diagnosis if they manifest clinical symptoms of a severe anaphylactic reaction.

Streszczenie

Oznaczenie stężenia tryptazy (Mast Cell Tryptase – MCT) w surowicy krwi znajduje coraz szersze zastosowanie w diagnostyce reakcji alergicznych z udziałem komórki tucznej. Może być wykorzystywane w celu oceny alergizującego działania leków podawanych podczas znieczulenia oraz w okresie okołooperacyjnym. Dotychczas rola tryptazy w organizmie nie została ostateczne określona. Pacjenci ze zwiększonym stężeniem MCT powinni być poddawani dalszym badaniom w celu poszukiwania środka sprawczego, potencjalnej reakcji alergicznej. Pacjenci z prawidłowym stężeniem tryptazy także powinni być poddawani dalszej diagnostyce, jeżeli mają kliniczne objawy ciężkiej reakcji anafilaktycznej.

Key words

tryptase, anaphylaxis, anesthesia, perioperative period

Słowa kluczowe

tryptaza, anafilaksja, znieczulenie, okres okołooperacyjny

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