Advances in Clinical and Experimental Medicine

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Advances in Clinical and Experimental Medicine

2011, vol. 20, nr 5, September-October, p. 623–626

Publication type: original article

Language: English

Colonic Diverticulosis and Risk of Large Bowel Adenomas

Uchyłkowatość jelita grubego a ryzyko występowania gruczolaków jelita grubego

Katarzyna Neubauer1,, Robert Dudkowiak2,, Radosław Kempiński1,, Adam Bąk3,, Leszek Paradowski1,

1 Department of Gastroenterology and Hepatology, Wroclaw Medical University, Poland

2 Dietetics Division at Department of Gastroenterology and Hepatology, Wroclaw Medical University, Poland

3 resident on gastroenterology in the Department of Gastroenterology and Hepatology, Wroclaw Medical University, Poland

Abstract

Background. The problem of the colonic diverticulosis, one of the most common diseases of the large bowel, as a risk factor for colonic adenomas and adenocarcinomas has not been fully clarified. The published results of the studies regarding this problem are contradictory.
Objectives. Evaluating the relationship between colonic diverticulosis and colonic adenomas.
Material and Methods. The group studied consisted of 3011 consecutive patients (1776 women, 1235 men, age 17–100 years, mean age 52.50 ± 16.36) which had endoscopic examination of the large bowel in the Endoscopy unit of the Department of Gastroenterology and Hepatology, Wroclaw Medical University. Retrospective analysis encompassed age, gender, presence and location of diverticula and presence and location of adenomas and adenocarcinomas.
Results. Diverticula were found in 425 patients (14.11%). Adenomas were found in 65 (15.3%) patients with diverticulosis and 190 (7.3%) patients without diverticulosis (OR = 2.28). Left-sided adenomas were found in 44 (10.35%) patients with left-sided diverticula and in 127 (4.9%) patients without diverticulosis (OR = 2.4). Colorectal cancer was present in 2.82% (n = 12) of patients with diverticulosis and in 3.79% (n = 98) of patients without diverticulosis. The presence of adenomas in relation to the presence of diverticula was statistically significant (chi-square analysis; p < 0.001). The presence of colorectal cancer in relation to the presence of diverticula was not statistically significant (p = 0.219).
Conclusion. The results of our study suggest that the presence of left-sided colonic diverticula may be considered as a risk factor for colonic adenomas.

Streszczenie

Wprowadzenie. Nie wyjaśniono jednoznacznie, czy uchyłkowatość jelita grubego, jedna z najczęstszych chorób okrężnicy, stanowi czynnik ryzyka rozwoju gruczolaków jelita grubego. Opublikowane wyniki badań poświęconych temu problemowi są sprzeczne.
Cel pracy. Ocena związku między uchyłkami i gruczolakami jelita grubego.
Materiał i metody. Grupę badaną tworzyło 3011 kolejnych pacjentów (1776 kobiet, 1235 mężczyzn, w wieku 17–100 lat, średni wiek 52,50 ± 16,36), u których przeprowadzono badanie endoskopowe jelita grubego w pracowni endoskopowej Kliniki Gastroenterologii i Hepatologii AM we Wrocławiu. W retrospektywnej analizie oceniano: wiek, płeć, obecność i umiejscowienie uchyłków, obecność i umiejscowienie gruczolaków i gruczolakoraków.
Wyniki. Uchyłki stwierdzono u 425 (14,11%) pacjentów, a gruczolaki – u 44 (10,7%) pacjentów z uchyłkowatością i 127 (4,9%) pacjentów bez uchyłkowatości. Raka jelita grubego rozpoznano u 2,82 (n = 12) pacjentów z uchyłkowatością i 3,79% (n = 98) pacjentów bez uchyłkowatości. Obecność gruczolaków w zależności od obecności uchyłków była istotna statystycznie (test c2; p < 0,001). Obecność raka jelita grubego w zależności od występowania uchyłków nie była istotna statystycznie (p = 0,219).
Wnioski. Wyniki badania własnego sugerują, że uchyłki w lewej połowie jelita grubego mogą być uważane za czynnik ryzyka gruczolaków jelita grubego.

Key words

colonic diverticulosis, colonic adenomas

Słowa kluczowe

uchyłkowatość jelita grubego, gruczolaki jelita grubego

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