Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 2.1
5-Year Impact Factor – 2.2
Scopus CiteScore – 3.4 (CiteScore Tracker 3.7)
Index Copernicus  – 161.11; MNiSW – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2011, vol. 20, nr 3, May-June, p. 385–390

Publication type: review article

Language: English

The Role of Omega-3 Unsaturated Fatty Acids in the Modification of Arrhythmogenesis

Rola nienasyconych kwasów tłuszczowych Omega-3 w modyfikacji procesu arytmogenezy

Agnieszka Noszczyk-Nowak1,, Urszula Pasławska1,, Józef Nicpoń1,

1 Department and Clinic of Internal Diseases of Horses, Dogs and Cats Wrocław University of Environmental and Life Sciences, Wrocław, Poland

Abstract

Over the past 30 years there has been an increasing interest in the role of polyunsaturated fatty acids (PUFAs) in reducing the risk of cardiovascular diseases. Omega-3 polyunsaturated fatty acids have anti-inflammatory, antiarrhythmic and anti-aggregating effects. They are used in the treatment of hypertension, hyperlipidemia and rheumatic arthritis. Recently, attention has been drawn to the antiarrhythmic effect of omega-3 acids, particularly DHA. However, numerous studies on animal models and observations in humans have not elucidated the mechanism of the antiarrhythmic effect of omega-3 acids. This study aims at presenting the mechanism and the role of omega-3 PUFAs in the modification of the arrhythmogenic process.

Streszczenie

Od 30 lat zwiększa się zainteresowanie badaczy rolą wielonienasyconych kwasów tłuszczowych (PUFA) w zmniejszaniu ryzyka chorób sercowo-naczyniowych. Wielonienasycone kwasy tłuszczowe omega-3 mają działanie przeciwzapalne, antyarytmiczne i przeciwagregacyjne. Kwasy omega-3 stosuje się w leczeniu nadciśnienia tętniczego, hiperlipidemii i choroby reumatycznej stawów. Od kilku lat podkreśla się dużą rolę antyarytmicznego wpływu kwasów omega-3, zwłaszcza kwasu kwasu dokosaheksaenowego (DHA). Mimo wielu badań przeprowadzonych na modelach zwierzęcych oraz obserwacji u ludzi, mechanizm antyarytmicznego działania kwasów omega-3 wciąż nie jest do końca wyjaśniony. Niniejsze opracowanie ma przybliżyć mechanizm i rolę kwasów omega-3 w modyfikacji procesu arytmogenezy.

Key words

polyunsaturated fatty acids, heart, arrhythmias

Słowa kluczowe

wielonienasycone kwasy tłuszczowe, serce, zaburzenia rytmu

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