Advances in Clinical and Experimental Medicine

Adv Clin Exp Med
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Advances in Clinical and Experimental Medicine

2006, vol. 15, nr 3, May-June, p. 421–426

Publication type: editorial article

Language: English

Creative Commons BY-NC-ND 3.0 Open Access

Photodynamic Therapy in Microbial Infections

Terapia fotodynamiczna w zakażeniach drobnoustrojowych

Giulio Jori1,, Gabrio Roncucci1,

1 Department of Biology, University of Padova, and Molteni Farmaceutici, Firenze, Italy

Abstract

While photodynamic therapy (PDT) is a well−established modality for the treatment of a variety of malignant tumors, several pathways are being explored to probe its potential for the treatment of a variety of non−cancerous conditions. A rapidly emerging application is the use of PDT against infectious diseases of microbial origin. In particular, oral candidiasis, periodontal diseases, and infected wounds can be considered as most suitable for PDT treatment. The association of the photosensitizer with the outer wall and/or the cytoplasmic membrane is a prerequisite for an efficient inactivation process. The main issue which needs to be addressed in order to make antimicrobial PDT a widely used modality is that of host toxicity. In fact, essentially all photosensitizers which are active against microbial cells are also phototoxic to human cells and tissues.

Streszczenie

Terapia fotodynamiczna (PDT) jest dobrze znaną metodą leczenia różnych złośliwych nowotworów, istnieje jednak wiele badań mających określić jej zastosowanie w chorobach nienowotworowych. Użycie PDT w chorobach zakaźnych jest coraz powszechniejsze. W szczególności należy brać pod uwagę kandydiazę jamy ustnej, choroby przyzębia i gojenie się zakażonych ran. Związanie się fotouczulacza ze ścianą zewnętrzną i/lub błoną cytoplazmatyczną jest warunkiem wstępnym skutecznego działania. Główny obszar, który wymaga jeszcze zbadania w ramach antydrobnoustrojowej PDT to toksyczność w komórkach gospodarza. Zasadniczo, wszystkie preparaty, które są aktywne w stosunku do komórek drobnoustrojów są także fototoksyczne dla komórek i tkanek ludzkich.

Key words

photodynamic therapy, microbia, photosensitizers

Słowa kluczowe

terapia fotodynamiczna, drobnoustroje, fotouczulacze

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