The journal entitled Postępy Medycyny Klinicznej i Doświadczalnej appeared quarterly since 1992. The originator, organizer and first editor-in-chief of the journal (1992-1997) was Professor Bogumił Halawa.
In 1998 the journal changed its name to Advances in Clinical and Experimental Medicine.
Prof. Leszek Paradowski was editor-in-chief from 1997-1999. In 1998 he initiated alterations in the profile and cover design of the journal which were accepted by the Editorial Board. The title was changed to Advances in Clinical and Experimental Medicine. Articles in English were welcomed. A number of outstanding representatives of medical science from Poland and abroad were invited to participate in the newly established International Editorial Staff.
Prof. Antonina Harłozińska-Szmyrka was editor-in-chief in years 2000-2005, in years 2006-2007 once again prof. Leszek Paradowski and prof. Maria Podolak-Dawidziak was editor-in-chief in years 2008-2016. Since 2017 the editor-in chief is prof. Maciej Bagłaj.
Since July 2005, original papers have been published only in English. Case reports are no longer accepted. The manuscripts are reviewed by two independent reviewers and a statistical reviewer, and English texts are proofread by a native speaker.
The journal has been indexed in several databases: Scopus, Ulrich’sTM International Periodicals Directory, Index Copernicus and since 2007 in Thomson Reuters databases: Science Citation Index Expanded i Journal Citation Reports/Science Edition.
In 2010 the journal obtained Impact Factor which is now 1.514. Articles published in the journal are worth 40 points among Polish journals according to the Polish Committee for Scientific Research and 155.19 pts according to the Index Copernicus.
Since November 7, 2012, Advances in Clinical and Experimental Medicine has been indexed and included in National Library of Medicine’s MEDLINE database. English abstracts printed in the journal are included and searchable using PubMed http://www.ncbi.nlm.nih.gov/pubmed.
"Enhancing the scientific standards and internationalization level of published scientific journals, and improving the level of information dissemination on scientific research outcomes or development work results" - project financed based on agreement No. 915/P-DUN/2019 from the resources of Ministry of Science and Higher Education allocated to science dissemination activities.